The Trisagion Prayers are a set of ancient prayers that begin each service of the Daily Cycle of divine services. They are also commonly used to begin one’s private prayers.

The-Trisagion-Τρισάγιον-Thrice-Holy-by-Angelboy

+ In the Name of the Father, and of the Son, and of the Holy Spirit.  Amen.

Glory be to Thee, our God; glory be to Thee.

O Heavenly King, the Comforter, the Spirit of Truth, Who art everywhere present and fillest all things; Treasury of blessings, and Giver of life:  Come and abide in us, and cleanse us of every impurity, and save our souls, O Good One.

+ Holy God, Holy and Mighty, Holy Immortal One, have mercy upon us.  (with bow)
+ Holy God, Holy and Mighty, Holy Immortal One, have mercy upon us.  (with bow)
+ Holy God, Holy and Mighty, Holy Immortal One, have mercy upon us.  (with bow)

+ Glory be to the Father, and to the Son, and to the Holy Ghost, both now and ever, and unto the ages of ages.  Amen.

Most-holy Trinity, have mercy on us:  Lord, cleanse us of our sins; Master, pardon our transgressions; Holy One, visit and heal our infirmities, for Thy Name’s sake.

Lord, have mercy.  Lord, have mercy.  Lord, have mercy.

+ Glory be to the Father, and to the Son, and to the Holy Spirit, both now and ever, and unto the ages of ages.  Amen.

+ Our Father, Who art in Heaven, hallowed be Thy Name.  Thy Kingdom come; Thy will be done, on earth as it is in Heaven.  Give us this day our daily bread; and forgive us our debts, as we forgive our debtors.  And lead us not into temptation, but deliver us from the evil one.

For Thine is the Kingdom, and the power, and the glory, + of the Father, and of the Son, and of the Holy Ghost, both now and ever, and unto the ages of ages.  Amen.

Meet it is in truth to bless thee, O Theotokos,
ever-blessèd and all-pure, and the Mother of our God.

More honourable than the Cherubim,
and more glorious incomparably than the Seraphim,
thou who without corruption gavest birth to God the Word,
the very Theotokos:  we thee magnify.

+ Glory be to the Father, and to the Son, and to the Holy Spirit, both now and ever, and unto the ages of ages.  Amen.

Lord, have mercy.  Lord, have mercy.  Lord, have mercy.

Through the prayers of our holy Fathers, + O Lord Jesus Christ our God, have mercy upon us.  Amen.

From John Damascene’s book “An Exposition of the Orthodox Faith”

The Cherubim

For we hold the words “Holy God” to refer to the Father, without limiting the title of divinity to Him alone, but acknowledging also as God the Son and the Holy Spirit: and the words “Holy and Mighty” we ascribe to the Son, without stripping the Father and the Holy Spirit of might: and the words “Holy and Immortal” we attribute to the Holy Spirit, without depriving the Father and the Son of immortality. For, indeed, we apply all the divine names simply and unconditionally to each of the subsistences in imitation of the divine Apostle’s words. “But to us there is but one God, the Father, of Whom are all things, and we in Him: and one Lord Jesus Christ by Whom are all things, and we by Him.” And, nevertheless, we follow Gregory the Theologian when he says, “But to us there is but one God, the Father, of Whom are all things, and one Lord Jesus Christ, through Whom are all things, and one Holy Spirit, in Whom are all things:” for the words “of Whom” and “through Whom” and “in Whom” do not divide the natures (for neither the prepositions nor the order of the names could ever be changed), but they characterize the properties of one unconfused nature. And this becomes clear from the fact that they are once more gathered into one, if only one reads with care these words of the same Apostle, Of Him and through Him and in Him are all things: to Him be the glory for ever and ever. Amen(4). For that the “Trisagium” refers not to the Son alone, but to the Holy Trinity, the divine and saintly Athanasius and Basil and Gregory, and all the band of the divinely-inspired Fathers bear witness: because, as a matter of fact, by the threefold holiness the Holy Seraphim suggest to us the three subsistences of the superessential Godhead.

The Seraphim

But by the one Lordship they denote the one essence and dominion of the supremely-divine Trinity. Gregory the Theologian of a truth says, “Thus, then, the Holy of Holies, which is completely veiled by the Seraphim, and is glorified with three consecrations, meet together in one lordship and one divinity.” This was the most beautiful and sublime philosophy of still another of our predecessors.

Ecclesiastical historians, then, say that once when the people of Constantinople were offering prayers to God to avert a threatened calamity, during Proclus’ tenure of the office of Archbishop, it happened that a boy was snatched up from among the people, and was taught by angelic teachers the “Thrice Holy” Hymn, “Thou Holy God, Holy and Mighty One, Holy and Immortal One, have mercy upon us:” and when once more he was restored to earth, he told what he had learned, and all the people sang the Hymn, and so the threatened calamity was averted. And in the fourth holy and great Ecumenical Council (I mean the one at Chalcedon), we are told that it was in this form that the Hymn was sung; for the minutes of this holy assembly so record it.

Damascene, St. John (2010-08-08). An Exact Exposition of the Orthodox Faith (Kindle Locations 1955-1981).  Kindle Edition.

For more information, See John Sanidopoulos’s blog: The Miracle of the Trisagion (“Thrice-Holy Hymn”)